Dr Eugene Sim is a well known cardiothoracic surgeon in Asia. He has one of the busiest practices and has performed more than 3000 cases of open heart surgery. He is renowned for his pioneering work in cardiac surgery. In Nov 1995 he was one of the first surgeons in Asia to perform minimally invasive direct coronary artery bypass grafting and has performed more than 100 such procedures to date. He was also the first surgeon in Asia to perform off-pump coronary artery bypass grafting using the Octopus stabilizer and has conducted many training courses to train surgeons in the use of this new technique.

He was one of the first surgeons in the region to perform thoracoscopic ligation of a patent ductus arteriosus in Dec 1995, Thoracoscopic anterior release for scoliosis in January 1996, thoracoscopic thymectomy in 1997, multivessel off pump coronary artery bypass grafting in July 1997 and robotic assisted coronary artery bypass surgery in April 2000. Dr Sim was appointed to the Board of Directors of the International Society of Minimally Invasive Cardiac Surgery in 2001.

Dr Sim has conducted more than 10 approved trials on new surgical techniques and equipment. He is a director of two biotechnology companies and sit on many scientific advisory boards. He has also been consulted by and advised various international medical device companies.

Dr Sim is renowned for his work on cell and myoblast transplant for heart failure. His work has been presented at the Scientific sessions of the American Heart Association, The American College of Cardiology, The European Association of Cardiovascular and Thoracic Surgery and the European Congress of Cardiology. On 14 May 2002, he become the first surgeon in Asia to perform pure myoblast transplantation in the failing heart.